Methylsulfonylmethane (MSM) is a naturally-occurring compound, with the formula (CH)₃SO₂. It is present in milk, fruits, and vegetables. In its compound form, it is found in the solid state and is colorless. It is a thermally-stable compound, with very low polarity. Methyl sulfone and dimethylsulfone (DMSO₂) are some of the other names of the compound. MSM occurs in the human body as a product of metabolism of dimethyl sulfoxide and certain amino acids like methionine and cysteine. It is high in sulfur content, and hence, used as a dietary supplement, consumed orally. Sometimes, it is taken along with glucosamine or chondroitin to obtain better results. Health Benefits MSM is effective in treating and preventing various health problems. It is used to treat patients suffering from osteoarthritis. It works effectively in relieving the symptoms of knee osteoarthritis. It also helps in the prevention of osteoarthritis. Researchers opine that it is capable of bringing down inflammation. Therefore, it is sometimes used to treat swelling of muscles and joints. It is effectual in the treatment of seasonal allergic rhinitis, or hay fever. It is also useful for the treatment of high cholesterol, hypertension, and some skin-related problems like wrinkles, stretch marks, etc. Side Effects Some of the side effects that have been commonly observed are nausea, diarrhea, fatigue, insomnia, dizziness, and headache. In case, any of these conditions worsen, or continue for a long period of time, then a doctor would have to be consulted immediately. Some other allergic reactions like skin rashes, swelling, itching, or trouble in breathing may also occur. Precautionary Measures It is not yet known if this drug is safe for everyone. This drug is not advisable to those suffering from severe chronic health-related problems. It should be avoided by those allergic to any food, dyes, or preservatives. It may not be good for pregnant women and lactating mothers. Under such situations, one should take these supplements, only after proper advice from the concerned doctor. There isn't sufficient evidence on adverse drug interactions, which is why, it is better to inform the doctor about other medications being used, even if herbal or any vitamins, before starting the dosage prescribed for these supplements. Unlike drugs, manufacturers of dietary supplements are not bound to seek the approval of FDA before producing or selling them. Therefore, it may happen that the dietary supplement that are sold over the counter may not prove to be that effective. Hence, it is essential to choose the supplements of the reputed manufacturers. This should be done only after appropriate consultation with a doctor. Disclaimer: This Buzzle article is for informative purposes only, and should not be used as a replacement for expert medical advice.