In today's world, E-commerce has occupied a special corner of the marketplace, and is a buzzing hub for entrepreneurs selling their wares online. It draws on technologies such as electronic money transfer and inventory management systems to promote its goods. It provides good opportunities to create new business relationships, by promoting business-to-business websites, as well as a good platform for budding entrepreneurs. And the only way to get your online presence noticed is through a website. The main contenders leading the race for hosting websites are Shopify and Squarespace. Shopify was launched in 2004, and was originally launched for small to medium businesses. Since its popularity, it has grown to envelop website hosting inside its domain. In 2010, it started the Built-a-Business competition to encourage budding entrepreneurs. The winner of this competition received a cash prize, as well as mentoring from renowned businessmen such as Richard Branson and Timothy Ferriss. It launched an iPad-centric application to accept payment from credit cards, as well as send items to faraway locations, without physically being there. Other than this, it supports many payment outlet apps to make transactions simple and secure. Squarespace is a website building as well as a blogging platform for novice users. It has a very intuitive interface, and makes website creation easy with drag and drop features. It makes editing of the website easy without switching between the site manager and the preview mode. It has additional features of free Typekit fonts and discounted Getty images, so as to make the website more presentable. Without further ado, we present a comparison of Shopify and Squarespace in E-commerce. Both websites offer a 14-day trial period, after which you have to choose a plan that suits your needs. Shopify is for those who wish to maintain an online business store, while Squarespace is for novice users who are still new to the process. As of 2012, E-commerce sales topped $1 trillion. With the above information, you can now join the booming online trade by making an informed decision.