bone remodeling process

Bone Remodeling Process

Bones continuously undergo remolding, which includes replacement of an old bone with a new one. This process includes basically five stages: quiescence phase, activation phase, resorption phase, reverse phase, and formation phase. Let us discuss these stages in detail.

1. Quiescence or Resting Phase This is the initial resting phase. In this stage, all the lining cells which are actually inactive osteoblasts, keep themselves attached to the surface. 2. Activation Phase Factors like micro-fracture, alteration in the release of substances like parathyroid hormone, insulin etc., activate the lining cells. These cells interact with the receptors which triggers pre-osteoclasts fusions and form multinucleotide osteoclasts. The osteoclasts gather on one site and form a small pit which is known as Howship's lacunae. 3. Resorption Phase As soon as the osteoclasts gather in the howship's lacunae, they start dissolving the bone. First they dissolve the matrix with the help of acidification and then they release lysosomial enzymes which help in the degradation of organic components of the bone. Once the bone is dissolved to the required extend, osteoclast undergo apoptosis or self-destruction. This is done to avoid excess resorption. 4. Reverse Phase This phase is carried out by the revere cells, which behave as macrophage and remove the debris produced during resorption. Due to the bone resorption, several growth factors are released which recruit osteoblasts at the site of resorption. 5. Formation phase Once osteoblasts generate in the resorption site, they start producing alkaline phosphate, which helps in the formation of new bone matrix, known as osteoid. Then they materialize and form a completely new bone. The surface of the bone again returns to its resting phase (quiescence phase) and this completes the bone remodeling cycle. All the cells which help to conduct the process are regulated by hormones. Any imbalance in the production of hormones can directly lead to the imbalance in the resorption and formation process. This may affect the body mass and bone health. Bone remodeling in one of the most important functions of our body, which helps in maintaining skeletal health and even maintains calcium levels in the body. So, take care of yourself to help this process function properly.

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