Glyburide that is commonly used to treat type 2 diabetes, should never be taken on an empty stomach, as it can cause a wide range of side effects. Generally, the patients are asked to take the medicine during breakfast or lunch. Glyburide Tablets Glyburide tablets are manufactured in two forms: micronized and nonmicronized. In the micronized variety, glyburide particle size is small. On the other hand, nonmicronized tablets have a larger particle size, so the dosage will vary depending upon whether it is micronized or nonmicronized. Nonmicronized Certain set of parameters are considered when deciding the dosage. For instance, people diagnosed with alarmingly high blood sugar levels start with a higher dosage than normally prescribed. In case, the patient is suffering from pre-existing health condition related to the liver or kidneys, then the dosage is less than what is usually recommended. In general, type 2 diabetes patients are initially put on a dosage that varies from 2.5 mg and 5 mg. This is the starting dosage and will depend on how severe is type 2 diabetes. The initial dosage can remain life long if type 2 diabetes is kept under control by following a healthy diet and exercise. A healthy lifestyle certainly prevents type 2 diabetes from aggravating, thus making it unnecessary to increase the dosage. However, in case the patient ignores lifestyle modifications, a further increase in blood sugar levels is observed and the doctor is left with no option but to increase the dosage, which may go up to 20 mg per day. Micronized Micronized glyburide users have to take a much lower dosage than those using its counterpart (non micronized). Initial dosage ranges between 2.5 mg and 5 mg per day. Large doses that can go up to 12 mg per day, may be prescribed to manage severe cases of type 2 diabetes. Keep in mind that this oral medication is a prescription medicine and hence doctor's recommendation is a must before purchasing this medicine. Also, when it comes to increasing the dosage, one has to consult the doctor to know whether it would be appropriate. Disclaimer: The information provided in this article is solely for educating the reader. It is not intended to be a substitute for the advice of a medical expert.